Genetics Workgroup

Scope

The workgroup charter is to study the interface between genetic research and the hierarchical structure of psychopathology dimensions. The overarching goal is to investigate how dimensional structural models such as HiTOP dovetail with our existing understanding of the transdiagnostic genetic architecture of psychopathology, and how quantitative and hierarchically organized phenotypes can facilitate future psychiatric genetic research. The scope spans both quantitative (i.e. twin and adoption studies) and molecular genetics research, including downstream genomic processes such as epigenetics and gene expression. The workgroup will aim to establish close collaborations with external researchers, consortia and datasets in the field of psychiatric and behavioral genetics.

Chairs

Katherine Jonas & Monika Waszczuk

Jonas (left), Waszczuk (right)

Members

Alexander J. Shackman
Anna Docherty
Ashley Watts
Aurina Arnatkeviciute
Avram Holmes
Avshalom Caspi
Benjamin B. Lahey
Bob Krueger
Brooke Sasia
Danielle Dick
David Zald
Elizabeth Aslinger
Frances Wang
Georgina Krebs
Giorgia Michelini
Irwin D. Waldman
J.D. Haltigan
James Li
Jeggan Tiego
Jennifer L. Tackett
Johan Ormel
John M Hettema
Jonathan Schaefer
Justin Luningham
Kristian Markon
Marina Bornovalova
Mark Bellgrove
Natalie Goulter
Nicholas Hoy
Roman Kotov
Susan C. South
Sylia Wilson

Workgroup Outputs

Waszczuk, M. A.*, Jonas, K. G.*, Bornovalova, M.,Breen, G., Bulik, C., Docherty, A., Eley, T. C., Hettema, J. M.,  Kotov,R., Krueger, R., Lencz, T., Li, J. J., Vassos, E., Waldman, I. (in press). Dimensional and Transdiagnostic Approaches in Psychiatric Genome-wide Association Studies. Molecular Psychiatry. Preprint * denotes joint first authors
‍
Waszczuk, M. A., Eaton, N. R., Krueger, R. F., Shackman, A. J., Waldman, I. D., Zald, D. H., Lahey, B. B., Patrick, C. J., Conway, C. C., Ormel, J., Hyman, S. E., Robinson, E. B., Fried, E. I., Forbes, M. K., Althoff, R. R., Bach, B., Chmielewski, M., de Young, C. G., Docherty, A., Forbush, K. T., Hallquist, M., Hopwood, C. J., Ivanova, M., Jonas, K. G., Latzman, R. D., Markon, K. E., Mullins-Sweatt, S. N., Pincus, A. L., Reininghaus, U., South, S. C., Tackett, J. L., Watson, D., Wright, A. G. C., Kotov, R. (2020). Redefining phenotypes to advance psychiatric genetics: Implications from Hierarchical Taxonomy of Psychopathology. Journal of Abnormal Psychology, 129, 143–161. Full text‍

Current Projects/Opportunities to get involved

Please reach out to Katherine and Monika if you are interested in getting involved.