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The Hierarchical Taxonomy of Psychopathology


Neurobiological Foundations Workgroup


The charge of this workgroup is to characterize emerging transdiagnostic dimensions by considering the interface between quantitative structural models of psychopathology dimensions (i.e., HiTOP) and approaches that begin with neurobiology. The workgroup aims to identify points of convergence and to more clearly articulate the transdiagnostic phenotypic and clinical endpoints of neurobiological variation. It also aims to facilitate identification of neural liability for, and expression of, various forms of psychopathology, as well as identification of models for relating neurobiological systems to clinical research and practice. The scope is not limited to research on humans, also providing an avenue through which nonhuman animal research can intersect with and inform HiTOP.


Colin G. DeYoung & Elizabeth A. Martin

Colin DeYoungElizabeth A. Martin

DeYoung (left), Martin (right)


Aaron Heller
Alex Fornito
Alexander J. Shackman
Alexandre Dombrovski
Anna Docherty
Anthony C. Ruocco
Antonia Kaczkurkin
Avram Holmes
Brady Nelson
Carrie McAdams
Christina Carlisi
Christopher J. Patrick
David H. Zald
Edward Bernat
Emily Perkins
Giorgia Michelini
Irwin D. Waldman
James Prisciandaro
Jamie Hanson
JD Allen
Jennifer L. Tackett
John D. Haltigan
Julia Linke
Kamran Afzali
Keanan Joyner
Kelsey E. Hagan
Liam Satchell
Marco Leyton
Mark Bellgrove
Michael Dretsch
Michael Hallquist
Michael T. Treadway
Natalie Goulter
Nicholas R. Eaton
Noah Venables
Philipp Homan
Rachael Grazioplene
Rany Abend
Raymond Chan
Rita Pasion
Robert D. Latzman (former co-chair)
Robert Krueger
Robert R. Althoff
Roman Kotov
Sarah Brislin
Scott D. Blain
Sylia Wilson
Timothy Allen
Vina Goghari
Sam Cooper
Robin Nusslock
Zoltan Sarnyai

Workgroup Outputs

DeYoung, C.G., Blain, S.D.,Latzman, R.D., Grazioplene, R.G., Haltigan, J.D., Kotov, R.., Michelini, G.,Venables, N.C., Docherty, A.R., Goghari, V.M., Kallen, A.M., Martin, E.A.,Palumbo, I.M., Patrick, C.J., Perkins, E.R., Shackman, A.J., Snyder, M.E.,Tobin, K.E., and the HiTOP Neurobiological Foundations Workgroup. (in press). The Hierarchical Taxonomy of Psychopathology (HiTOP) and the search for neurobiological substrates of mental illness: A systematic review and roadmap for future research. Journal of Psychopathology and Clinical Science. Preprint

Latzman, R. D., DeYoung, C. G., & The HiTOP Neurobiological Foundations Workgroup. (2020). Using empirically-derived dimensional phenotypes to accelerate clinical neuroscience: The Hierarchical Taxonomy of Psychopathology (HiTop) framework. Neuropsychopharmacology, 45(7), 1083–1085. Full text

Pasion, R., Ribes-Guardiola, P., Patrick, C., Steward, R.A., Paiva, T.O., Macedo, I., Barbosa, F., Brislin, S.J., Martin, E.A., Blain, S.D., Ruocco, A.C., Cooper, S.E., Tiego, J., Wilson, S., Goghari, V.M., and the HiTOP Neurobiological Foundations Workgroup (2023). Modeling relations of ERP factors with broader versus narrower dimensions of externalizing psychopathology. Journal of Psychopathology and Clinical Science, 132, 867-880. doi: 10.1037/abn0000856

Perkins, E. R.,* Joyner, K. J.,* Patrick, C. J., Bartholow, B. D., Latzman, R. D., DeYoung, C. G., Kotov, R., Reininghaus, U., Cooper, S. E., Afzali, M. H., Docherty, A. R., Dretsch, M. N., Eaton, N. R., Goghari, V. M., Haltigan, J. D., Krueger, R. F., Martin, E. A., Michelini, G., Ruocco, A. C., Tackett, J. L., Venables, N. C., Waldman, I. D., & Zald, D. H. (2020). Neurobiology and the Hierarchical Taxonomy of Psychopathology: Progress toward ontogenetically informed and clinically useful nosology. Dialogues in Clinical Neuroscience, 22, 51-63. Full text

Tiego, J., Martin, E.A., DeYoung, C.G., Hagan, K., Cooper, S.E., Pasion, R., Satchell, L., Shackman, A.J., Bellgrove, M.A., Fornito, A., and the HiTOP Neurobiological Foundations Work Group (in press). Precision behavioral phenotyping as a strategy for uncovering the biological correlates of psychopathology. Nature Mental Health, 1, 304-315. doi: 10.1038/s44220-023-00057-5

Current Projects/Opportunities to get involved

The workgroup is currently exploring possibilities of incorporating the HiTOP-SR measure with MRI and EEG data collection.

Get Involved in the HiTOP Effort

New members are always welcome